Presentación simultánea de pénfigos vulgar y foliáceo
Resumo
El pénfigo foliáceo y el pénfigo vulgar son enfermedades autoinmunes caracterizadas por vesículas y ampollas que se rompen fácilmente dejando erosiones superficiales. Las ampollas están localizadas en diferentes sitios de la epidermis dependiendo del perfil inmunológico con el que cursen. Se reporta el caso de una paciente con presentación simultánea de pénfigo vulgar y pénfigo foliáceo, una asociación de baja incidencia con pocos casos informados en la literatura.
Downloads
Referências
Amagai M. Adhesion molecules I: Keratinocyte-keratinocyte interactions; cadherins and pemphigus. J Invest Dermatol. 1995;104:146-52.
Feliciani C, Motta A, Castellaneta M, Federica M, De Benedetto A, Toto P, et al. Coexisting pemphigus vulgaris and pemphigus foliaceus in the same patient. Int J Dermatol. 2005;44:139-41.
Amagai M. Autoimmunity against desmosomal cadherines in pemphigus. J Dermatol Sci. 1999;92-102.
Izumi T, Seishima M, Satoh S, Ito A, Kamiya H, Kitajima Y. Pemphigus with features of both vulgaris and foliaceus variants, associated with antibodies to 160 and 130 kDa antigens. Br J Dermatol. 1998;139:688-92.
Martel P, Cordel N, Courville P, Gilbert D, Musette P, Joly P. Pemphigus with clinical, histological and immunological features of both vulgaris and foliaceus subtypes. Br J Dermatol. 2002;147:1263.
Harman KE, Gratian MJ, Shirlaw PJ, Bhogal BS, Challacombe SJ, Black MM. The transition of pemphigus vulgaris into pemphigus foliaceus: a reflection of changing desmoglein 1 and 3 autoantibody levels in pemphigus vulgaris. Br J Dermatol. 2002;146:684-67.
Joly P, Litrowski N. Pemphigus group (vulgaris, vegetans, foliaceus, hepetiformis, brasiliensis). Clin Dermatol. 2011;29:432-6.
Kimoto M, Ohyama M, Hata Y, Amagai M, Nishikawa T. A case of pemphigus foliaceus which occurred after five years of remission from pemphigus vulgaris. Dermatology. 2001;203:174-6.
Komai A, Amagai M, Ishii K, Nishikawa T, Chorzelski T, Matsuo I, et al. The clinical transition between pemphigus foliaceus and pemphigus vulgaris correlates well with the changes in autoantibody profile assessed by an enzyme-linked inmmunosorbent assay. Br J Dermatol. 2001;144:1177-82.
Lunardon L, Tsai KJ, Propert KJ, Fett N, Stanley JR, Werth VP, et al. Adjuvant rituximab therapy of pemphigus: a single-center experience with 31 patients. Arch Dermatol. 2012;148:1031-6.
